Scientific Publications

Latest Publications

A Phase 1, Open Label, Randomized, Single Dose, Parallel Group Safety and Bioavailability Study of BION-1301 Administered by Intravenous (IV) and Subcutaneous (SC) Routes
ISN World Congress of Nephrology 2021 | April 2021

Selective ETA Antagonist Atrasentan, Rapidly Reduces Albuminuria and Downregulates Intra-renal Pro-Inflammatory and Pro-Fibrotic Transcriptional Networks in the g-ddY Mouse Model of Spontaneous IgA Nephropathy
ISN World Congress of Nephrology 2021 | April 2021

Human Renal Mesangial Cell Activation Induced by Endothelin-1 or IgA Nephropathy Patient Immune Derived Complexes is Blocked by Selective ETA Antagonist Atrasentan
ISN World Congress of Nephrology 2021 | April 2021

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Atrasentan in Patients with IgA Nephropathy
(The ALIGN Study)
ISN World Congress of Nephrology 2021 | April 2021

Atrasentan in Patients with Proteinuric Glomerular Diseases (The AFFINITY Study)
ISN World Congress of Nephrology 2021 | April 2021

Discovery of CHK-336: A First-in-Class, Liver-Targeted, Small Molecule Inhibitor of Lactate Dehydrogenase for the Treatment of Hyperoxaluria
ISN World Congress of Nephrology 2021 | April 2021

atrasentan Publications

Selective ETA Antagonist Atrasentan, Rapidly Reduces Albuminuria and Downregulates Intra-renal Pro-Inflammatory and Pro-Fibrotic Transcriptional Networks in the g-ddY Mouse Model of Spontaneous IgA Nephropathy
ISN World Congress of Nephrology 2021 | April 2021

Human Renal Mesangial Cell Activation Induced by Endothelin-1 or IgA Nephropathy Patient Immune Derived Complexes is Blocked by Selective ETA Antagonist Atrasentan
ISN World Congress of Nephrology 2021 | April 2021

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Atrasentan in Patients with IgA Nephropathy
(The ALIGN Study)
ISN World Congress of Nephrology 2021 | April 2021

Atrasentan in Patients with Proteinuric Glomerular Diseases (The AFFINITY Study)
ISN World Congress of Nephrology 2021 | April 2021

A Phase 3, Randomized, Double‐Blind, Placebo‐Controlled Study of Atrasentan in Patients with IgA Nephropathy (The ALIGN Study)
American Society of Nephrology Kidney Week 2020 Reimagined | October 2020

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial
The Lancet | April 2019

SONAR propels endothelin A receptor antagonists to success
The Lancet | April 2019

A turning point for chronic kidney disease in diabetes
The Lancet | April 2019

Determining the optimal dose of atrasentan by evaluating the exposure-response relationships of albuminuria and bodyweight
Diabetes Obes Metab. | February 2018

The Endothelin Antagonist Atrasentan Lowers Residual Albuminuria in Patients with Type 2 Diabetic Nephropathy
Journal of the American Society of Nephrology | 2014

Endothelin and Endothelin Antagonists in Chronic Kidney Disease
Kidney Int. | November 2014

BION-1301 Publications

A Phase 1, Open Label, Randomized, Single Dose, Parallel Group Safety and Bioavailability Study of BION-1301 Administered by Intravenous (IV) and Subcutaneous (SC) Routes
ISN World Congress of Nephrology 2021 | April 2021

Results of a Phase 1 Trial to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BION-1301 in Healthy Volunteers (Encore)
American Society of Nephrology Kidney Week 2020 Reimagined | October 2020

Results of a Phase 1 Trial to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BION-1301 in Healthy Volunteers (Encore)
Asian Pacific Congress of Nephrology | October 2020

Results of a Phase 1 Trial to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BION-1301 in Healthy Volunteers
European Renal Association – European Dialysis and Transplant Association | June 2020

BION-1301, a Fully Blocking Antibody Targeting APRIL for the Treatment of IgA Nephropathy: Assessment of Safety, Toxicokinetics and Pharmacodynamics in Long-Term Nonclinical Studies
European Renal Association – European Dialysis and Transplant Association | June 2020

Nonclinical Safety and PK/PD of BION-1301, a Fully Blocking Antibody Targeting A PRoliferation Inducing Ligand (APRIL) for the Treatment of IgA Nephropathy
American Society of Nephrology Kidney Week | November 2019

BION-1301: a Novel fully Blocking APRIL Antibody for the Treatment of IgA Nephropathy
American Society of Nephrology | October 2018

Research and Discovery Publications

Single Cell Transcriptomic Analysis to Define Cellular Heterogeneity in Human ADPKD
American Society of Nephrology Kidney Week 2020 Reimagined | October 2020