Clinical Trials

At Chinook Therapeutics, we believe our work should be informed by patients and for patients. Our partnerships with leading Patient Advocacy Organizations enable us to better understand our patients and their needs. We’re also committed to improving patient access and representation in our clinical trials through financial assistance or compensation for out-of-pocket costs. We thank patients and their families for their interest in our clinical trials. Clinical trial participation makes our research and advances in the treatment of kidney disease possible.

If you have any questions about our clinical trials, please speak with your physician. 

Indication Program* Trial Number Trial Name
IgA nephropathy (IgAN) Atrasentan​ NCT04573478 Phase 3 Study of Atrasentan in IgA Nephropathy (The ALIGN Study)
IgA nephropathy (IgAN) Atrasentan​ NCT04573920 Phase 2 Basket Study of Atrasentan in Proteinuric Glomerular Disease (The AFFINITY Study)
Alport Syndrome
Primary Focal Segmental Glomerulosclerosis (FSGS)
Diabetic Kidney Disease
IgA nephropathy (IgAN) Atrasentan NCT05834738 Phase 2 Study of Atrasentan in IgA Nephropathy in Combination with SGLT2i (The ASSIST Study)
IgA nephropathy (IgAN) Zigakibart (BION-1301) NCT05852938 Phase 3 Study of Zigakibart in Adults with IgA Nephropathy (The BEYOND Study)
IgA nephropathy (IgAN) Zigakibart (BION-1301) NCT03945318 Phase 1/2 Study of Zigakibart in Healthy Volunteers and Adults with IgA Nephropathy
Primary and Idiopathic Hyperoxalurias CHK-336 NCT05367661 Phase 1 Study of CHK-336 in Healthy Volunteers 

*Our programs are investigational therapies. An investigational therapy is a drug that has not yet been approved by the FDA. Efficacy and safety have not been established, and there is no guarantee that it will become commercially available for the use(s) under investigation. Participation in one of our clinical trials is the most appropriate way to access our investigational therapies.

Patient Resources

The following is a list of resources for patients and families with reliable information related to kidney health and clinical trials. is a registry with information about the location of clinical trials, their design and purpose, and eligibility criteria. Search the database for Chinook trials or other clinical trials.

Center for Information and Research on Clinical Research Participation (CISCRP)

CISCRP is a nonprofit organization dedicated to educating and informing the public, patients, medical/research communities, the media, and policy makers about clinical research.

Advocacy Partners

The following is a list of our advocacy partners, that can provide patients and families with reliable information related to kidney health and clinical trials.

AAKP logo

AAKP is the oldest and largest, independent kidney patient organization in the U.S. and is dedicated to improving the lives and long-term outcomes of kidney patients through education, advocacy, patient engagement and the fostering of patient communities.

Alport Syndrome logo

Alport Syndrome Foundation is the leading independent non-profit organization in the United States educating and giving a voice to the Alport syndrome community through education, empowerment, advocacy and research.

AKF logo

AKF is dedicated to ensuring that every kidney patient has access to health care and people at risk for kidney disease are empowered to prevent it.

Can Solce CKD logo

Can-SOLVE CKD is a pan-Canadian patient-oriented kidney research network. In partnership with patients, researchers, health care providers, and policy-makers, they are working to transform treatment and care for Canadians living with or at risk for chronic kidney disease.

IGA Nephropasthy logo

A patient-centric non-profit organization focused on finding a cure for IgA nephropathy through funding research, using patient advocacy to empower patients, and building a network of support.

National Kidney Foundation logo

The NKF is a major non-profit health organization focused on awareness, education, prevention and treatment of kidney disease.

NephCure logo

NephCure’s mission is to accelerate research for effective treatments for rare forms of Nephrotic Syndrome, and to provide education and support that will improve the lives of those affected by these protein-spilling kidney diseases.

OHF logo

The Oxalosis & Hyperoxaluria Foundation (OHF) is dedicated to finding treatments and a cure for all forms of hyperoxaluria.​